Increased lung volume in infants and toddlers at high compared to low altitude
| Autor: | Federico Bonilla, Myriam R. Martínez, Zhansheng Yu, Celia Cabana, Robert S. Tepper, Conrado J. Llapur, María M. Caram |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
Low altitude Lung business.industry Physiology respiratory system Effects of high altitude on humans Chronic hypoxia respiratory tract diseases Vascular endothelial growth factor chemistry.chemical_compound Functional residual capacity medicine.anatomical_structure chemistry Erythropoietin Pediatrics Perinatology and Child Health Immunology medicine Lung volumes business medicine.drug |
| Zdroj: | Pediatric Pulmonology. 48:1224-1230 |
| ISSN: | 8755-6863 |
| DOI: | 10.1002/ppul.22764 |
| Popis: | Children and adults residing at high altitude (HA) compared to low altitude (LA) have larger lung volumes; however, it is unknown whether this response to chronic hypoxia begins early in life. Our objective was to determine whether infants and toddlers at HA have larger lung volumes compared to infants and toddlers at LA. Oxygen saturation (SaO2 ), functional residual capacity (FRC), as well as serum levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were measured in infants and toddlers from HA (N = 50; 3,440 m) and LA (N = 35; 440 m). There were no significant differences in somatic size for HA and LA subjects; however, HA subjects had significantly lower SaO2 (88.5% vs. 96.7%; P |
| Databáze: | OpenAIRE |
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