3-Oxo-4,4,4-trifluorobutyronitriles as building blocks of trifluoromethyl substituted heterocycles2.Heterocyclization to 3-aryl-4-trifluoromethyl-2H-1-benzopyran-2-ones under hoesch reaction conditions

Autor:	H. Kikukawa, Tarozaemon Nishiwaki
Rok vydání:	1994
Předmět:	Dibutyl ether chemistry.chemical_compound Trifluoromethyl chemistry Bicyclic molecule Yield (chemistry) Aryl Organic Chemistry Hoesch reaction Medicinal chemistry Derivative (chemistry) Catalysis
Zdroj:	Journal of Heterocyclic Chemistry. 31:889-892
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570310433
Popis:	Resorcinol and 5-methylresorcinol, respectively, react with 3-oxo-2- aryl-4,4,4-trifluorobutyronitrile using zinc chloride as a catalyst in dibutyl ether under the Hoesch reaction conditions to give a low yield of 3-aryl-7-hydroxy-4-trifluoromethyl- or 3-aryl-5-hydroxy-7-methyl-4- trifluoromethyl-2H-1-benzopyran-2-ones. However, the related reaction with m-methoxyphenol was found to produce poor yields of 3-aryl-1-me- thoxy-4-trifluoromethyl-2H-1-benzopyran-2-one and its 3,4-dihydro-4-hy- droxy derivative
Databáze:	OpenAIRE
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