Initiiert fetales Oxytocin den Geburtsbeginn beim Menschen? Eine Hypothese
Autor: | A.-R. Fuchs, Fritz Fuchs, M. S. Soloff, Peter Husslein |
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Rok vydání: | 1982 |
Předmět: |
endocrine system
Fetus medicine.medical_specialty Pregnancy medicine.medical_treatment Decidua Prostaglandin production Obstetrics and Gynecology Biology medicine.disease Oxytocin receptor medicine.anatomical_structure Endocrinology Oxytocin Internal medicine Maternity and Midwifery medicine Receptor reproductive and urinary physiology hormones hormone substitutes and hormone antagonists Prostaglandin E medicine.drug |
Zdroj: | Geburtshilfe und Frauenheilkunde. 42:579-582 |
ISSN: | 1438-8804 0016-5751 |
DOI: | 10.1055/s-2008-1036924 |
Popis: | The concentration of specific oxytocin receptors increases during pregnancy and reaches a maximum at term after the onset of spontaneous labour. This constitutes a biochemical explanation for the well-known increase of oxytocin sensitivity during pregnancy. Oxytocin receptors were also found in human decidua and their concentration increased similarly. Based on these results the hypothesis was set up that oxytocin leads to an increase in prostaglandin production though specific receptors in decidua. Under specific incubation circumstances oxytocin indeed increased prostaglandin E and prostaglandin F synthesis of decidual tissue. In induction of labour with oxytocin PGF-levels in the maternal peripheral plasma increased significantly in all women in whom induction was successful. Since it is known that the fetus secretes considerable amounts of oxytocin in case of labour of spontaneous onset the hypothesis was set up that fetal oxytocin may initiate human labour by the mechanisms described above. |
Databáze: | OpenAIRE |
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