Early Detection of Pancreatic Cancer in Type 2 Diabetes Mellitus Patients Based on 1H NMR Metabolomics
| Autor: | Lenka Michálková, Bohus Bunganic, Štěpán Horník, Lucie Habartová, Vladimír Setnička, Jan Sýkora |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030102 biochemistry & molecular biology business.industry Health condition Type 2 Diabetes Mellitus Early detection General Chemistry medicine.disease Biochemistry Gastroenterology 03 medical and health sciences 030104 developmental biology Metabolomics Internal medicine Pancreatic cancer Diabetes mellitus Blood plasma medicine business Pancreatogenic diabetes |
| Zdroj: | Journal of Proteome Research. 20:1744-1753 |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/acs.jproteome.0c00990 |
| Popis: | The association of pancreatic cancer with type 2 diabetes mellitus was investigated by 1H NMR metabolomic analysis of blood plasma. Concentration data of 58 metabolites enabled discrimination of pancreatic cancer (PC) patients from healthy controls (HC) and long-term type 2 diabetes mellitus (T2DM) patients. A panel of eight metabolites was proposed and successfully tested for group discrimination. Furthermore, a prediction model for the identification of at-risk individuals for future development of pancreatic cancer was built and tested on recent-onset diabetes mellitus (RODM) patients. Six of 59 RODM samples were assessed as PC with an accuracy of more than 80%. The health condition of these individuals was re-examined, and in four cases, a correlation to the prediction was found. The current health condition can be retrospectively attributed to misdiagnosed pancreatogenic diabetes or to early-stage pancreatic cancer. |
| Databáze: | OpenAIRE |
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