A glimpse in critical attributes to design cutaneous film forming systems based on ammonium methacrylate
| Autor: | Francesco Cilurzo, Chiara G.M. Gennari, Umberto M. Musazzi, Francesca Selmin, Silvia Franzè, G.M.G. Quaroni, Antonella Casiraghi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chromatography Materials science Plasticizer Pharmaceutical Science 02 engineering and technology Polymer Permeation 021001 nanoscience & nanotechnology Methacrylate 030226 pharmacology & pharmacy Solvent 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Stratum corneum medicine Acetone 0210 nano-technology Triacetin Nuclear chemistry |
| Zdroj: | Journal of Drug Delivery Science and Technology. 41:157-163 |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2017.07.009 |
| Popis: | A film forming system based on Eudragit ® RL (EuRL) was designed aiming to evidence the relevance of formulative variables on the following critical attributes: film forming rate, outward stickiness, Young modulus ( Y ) and in vitro drug skin permeation. Different solvent mixtures (acetone and isopropanol in the range from 10:90 to 40:60 v/v), polymer concentrations (10–30% w/w), and plasticizer types and concentrations (triacetin or tributyl citrate, up to 50% of EuRL) were evaluated. EuRL dissolved in 80/20 or 70/30 v/v isopropanol/acetone mixtures at the concentration of 20% and plasticized with tributyl citrate (20 or 30% with respect to polymer) gave films with negligible stickiness and Y lower than 3 MPa. This value should assure an intimate and prolonged contact with the skin since it was significantly lower than Y of human stratum corneum (55 MPa). The optimized formulations were able to sustain the skin permeation of ibubrofen, ketoprofen and flurbiprofen and evidenced the importance of each formulative variable. In particular, relatively slow solvent evaporation rate can determine an initial “burst” effect and can influence the drug permeation in the initial hours. Conversely, when the solvent evaporation rate is not discriminant, the thermodynamic activity remains the main parameter driving the skin permeation. |
| Databáze: | OpenAIRE |
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