Change in the Equilibrium of the Levels of Free and Bound Forms of α1-Microglobulin and Ulinastatin in Patients with Mood Disorders
| Autor: | Koichi Kaku, Shuji Takaori, Tadahiro Shikimi, Jun Uegaki |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Beta-2 microglobulin Case-control study Healthy subjects Positive correlation Ulinastatin medicine.disease Psychiatry and Mental health chemistry.chemical_compound Neuropsychology and Physiological Psychology Endocrinology chemistry Mood disorders Internal medicine medicine In patient Psychology Biological Psychiatry Serum cortisol |
| Zdroj: | Neuropsychobiology. 45:62-66 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000048678 |
| Popis: | We have previously found that the relationship between the urinary content of α1-microglobulin (α1M) and ulinastatin (UT) in patients with mood disorders (MD) differs from that in age-matched healthy subjects. Similar results were obtained for the relationship between the content of free forms of α1M and UT in serum, and that between the ratio of the content of free form to the total (free + bound forms) content (F/T ratio) of α1M and UT in serum. As for the content of α1M and UT in serum, statistical differences were not observed between MD patients and healthy subjects with regard to the respective total content of α1M and UT nor the F/T ratio of α1M, whereas the F/T ratio of UT was significantly (p < 0.05) lower in MD patients than in healthy subjects. Furthermore, the serum cortisol content was higher in MD patients than in healthy subjects, and a positive correlation between cortisol content and F/T ratios of UT was demonstrated in the present investigation. These results suggest that the equilibrium of free and bound forms of UT in serum, but not of α1M , tends to decrease the free-form level of UT in MD patients. The efficiency of cortisol, which might increase the free-form level of UT, markedly deteriorated in MD patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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