Enantioselective N-heterocyclic carbene-catalyzed nucleophilic dearomatization of alkyl pyridiniums
| Autor: | Darrin M. Flanigan, Tomislav Rovis |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry High selectivity Enantioselective synthesis General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Nucleophile Organic chemistry Pyridinium Carbene Alkyl |
| Zdroj: | Chemical Science. 8:6566-6569 |
| ISSN: | 2041-6539 2041-6520 |
| DOI: | 10.1039/c7sc02648j |
| Popis: | NHC-catalyzed nucleophilic dearomatization of alkyl pyridiniums has been achieved to generate 1,4-dihydropyridines with high enantioselectivity. This is a rare example of catalytic, asymmetric addition of a nucleophile to the activated pyridinium that prefers C-4 functionalization leading to the 1,4-dihydropyridine with high selectivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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