Biosynthesis of nocardicin A by Nocardia uniformis subsp. tsuyamanensis. I. Inco oration of 14C-amino acids into nocardicin A by growing cells

Autor:	Hiroshi Imanaka, Junji Hosoda, Hatsuo Aoki, Toshio Konomi, Naoki Tani, Shigeyoshi Ohsawa
Rok vydání:	1977
Předmět:	chemistry.chemical_classification Nocardia uniformis Stereochemistry Homoserine General Biochemistry Genetics and Molecular Biology Nocardicin A Amino acid Serine chemistry.chemical_compound Biochemistry chemistry Biosynthesis Moiety Tyrosine General Agricultural and Biological Sciences
Zdroj:	Agricultural and Biological Chemistry. 41:2007-2012
ISSN:	1881-1280 0002-1369
DOI:	10.1271/bbb1961.41.2007
Popis:	The biosynthesis of nocardicin A by Nocardia uniformis subsp. tsuyamanensis was studied. L-Tyrosine, p-hydroxyphenylpyruvic acid, DL-p-hydroxymandelic acid and L-p-hydroxyphenylglycine have stimulatory effect on the production of nocardicin A. In feeding experiment with 14C-amino acids, L-tyrosine-U-14C, L-serine-U-14C, glycine-U-14C and L-homoserine-U-14C were incorporated into nocardicin A. Tyrosine was incorporated into the two aromatic rings of nocardicin A, serine into the β-lactam ring and homoserine into the 3-amino-3-carboxypropoxy moiety. Thus the precursors of nocardicin A are tyrosine, serine and homoserine.
Databáze:	OpenAIRE
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