Enteral L-citrulline supplementation in preterm infants is safe and effective in increasing plasma arginine and citrulline levels – A pilot randomized-controlled trial

Autor: Sunil Jain, Amna Qasim, Snigdha Bhatia, Maria Franco Fuenmayor, Mohammad Mehdi
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2839000/v1
Popis: Objective Deficiencies of citrulline and arginine have been associated with adverse outcomes in preterm-infants (PI) and data regarding enteral supplementation in PI is unknown. Study Design: This randomized-controlled-trial [NCT03649932] included 42 PI (gestational age ≤ 33 weeks) randomized to receive enteral L-citrulline in low (100 mg/kg/day), medium (200 mg/kg/day) and high-dose (300 mg/kg/day) groups for 7 days. Plasma citrulline and arginine levels were obtained pre-and-post supplementation and efficacy was determined by a significant increase in levels after supplementation. A p
Databáze: OpenAIRE