Anticipating tumor metastasis by circulating tumor cells captured by acoustic microstreaming
| Autor: | Lin Feng, Fumihito Arai, Dixiao Chen, Yuguo Dai, Bin Song, Xue Bai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
business.industry Tumor cells 02 engineering and technology Whole blood sample 021001 nanoscience & nanotechnology Metastatic tumor medicine.disease Metastasis 03 medical and health sciences Circulating tumor cell Cancer cell Cancer research Medicine Normal blood 0210 nano-technology business Solid tumor 030304 developmental biology |
| Zdroj: | IROS |
| Popis: | Circulating tumor cells (CTCs) are the primary cause of tumor metastasis after surgery. Metastatic tumor recurrence is the leading reason of cancer death. It is prerequisite to develop a platform for CTCs separation to predict the cancer cell transfer in important organs. Herein, a novel acoustic microfluidic device was designed to capture the "true" CTCs from the whole blood sample. The blood got from the mice with breast tumors removed. There are some CTCs that have escaped from the solid tumor contained in these blood samples, instead of artificially mixing individual tumor cells into normal blood. In addition, the predictions of tumor prognosis are made based on the number of CTCs captured by the acoustofluidic device. Finally, the prediction has been confirmed through long-term observation of mice with tumor excised. The acoustofluidic device can efficiently capture CTCs and predict the tumor metastasis, which can help clinicians plan follow-up treatment for patients who have had their tumors surgically removed. |
| Databáze: | OpenAIRE |
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