Sex differences in acute coronary syndrome management and in 12-month case-fatality trends: data from the French MONICA registries

Autor: V Gauthier, M Montaye, J Ferrieres, S Huo Yung Kai, K Biasch, M Moitry, P Amouyel, J Dallongeville, A Meirhaeghe
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Preventive Cardiology. 29
ISSN: 2047-4881
2047-4873
DOI: 10.1093/eurjpc/zwac056.315
Popis: Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Santé publique France, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Background Earlier studies, have reported sex differences in clinical presentation, management and outcomes of acute coronary syndrome (ACS) which have prompted the medical community to take actions to erase these differences. To our knowledge, there has been no recent analysis of sex difference trends in ACS management, to assess whether these differences have been attenuated over time. Aim To assess recent sex differences trends in ACS characteristics, management and associated mortality. Methods We assessed all men and women (aged 35-74) hospitalized for an incident (first) ACS, in the 3 distinct geographical areas covered by the MONICA registries in the north, east and south-west of France, during a 12-month period in 2006 and a 6-month period in 2016. We analyzed the patients’ clinical, biochemical, electrocardiographic and care-related data, and their vital status 12 months after the ACS. Results We analyzed 2023 incident ACSs in 2006 and 1173 in 2016. The proportion of men was three times higher than that of women in both periods. In 2016, women were younger (62.0 y in 2006 and 60.4 y in 2016; p=0.06) and men were older (57.6 y in 2006 and 59.0 y in 2016; p Conclusions The results of the present study evidenced an improvement over time in the management of ACS. However, although there were no longer sex differences in the patients’ age and clinical presentation, women with ACS were still less likely than men to receive revascularization and pharmacological treatments in 2016.
Databáze: OpenAIRE
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