| Autor: |
D. Lanens, G.V. Peersman, Roger Dommisse, F. L. Van de Vyver, J.J. Martin, F.C. Alderweireldt |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Images of the Twenty-First Century. Proceedings of the Annual International Engineering in Medicine and Biology Society. |
| DOI: |
10.1109/iembs.1989.95881 |
| Popis: |
An animal model of multiple sclerosis (MS) was studied to establish the neuropathological correlation of abnormal nuclear magnetic resonance (NMR) signals. Appropriate radio frequency coils are used to allow NMR imaging experiments with very high spatial resolution. Materials and methods for experiments on chronic recurrent experimental allergic encephalomyelitis (CREAE) in guinea pits are discussed, and a morphological study is described. CREAE was chosen as the animal model because of its similarities to MS. It was found that the lesions could be visualized by NMR imaging in vivo and in vitro. For the in vivo measurement there was a mini-extent required for the lesion to be detected. In vitro the sites and sizes of the areas with abnormal NMR signal correlated closely with inflammation and demyelination. > |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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