Steroid-Induced Iatrogenic Adrenal Insufficiency in Children: A Literature Review
| Autor: | Shogo Akahoshi, Yukihiro Hasegawa |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
medicine.diagnostic_test business.industry media_common.quotation_subject ACTH stimulation test Physiology Adrenal crisis 030209 endocrinology & metabolism Appetite Adrenocorticotropic hormone Hypoglycemia medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Adrenal insufficiency 030212 general & internal medicine medicine.symptom business Hypothalamic–pituitary–adrenal axis Hydrocortisone medicine.drug media_common |
| Zdroj: | Endocrines. 1:125-137 |
| ISSN: | 2673-396X |
| DOI: | 10.3390/endocrines1020012 |
| Popis: | The present review focuses on steroid-induced adrenal insufficiency (SIAI) in children and discusses the latest findings by surveying recent studies. SIAI is a condition involving adrenocorticotropic hormone (ACTH) and cortisol suppression due to high doses or prolonged administration of glucocorticoids. While its chronic symptoms, such as fatigue and loss of appetite, are nonspecific, exposure to physical stressors, such as infection and surgery, increases the risk of adrenal crisis development accompanied by hypoglycemia, hypotension, or shock. The low-dose ACTH stimulation test is generally used for diagnosis, and the early morning serum cortisol level has also been shown to be useful in screening for the condition. Medical management includes gradually reducing the amount of steroid treatment, continuing administration of hydrocortisone corresponding to the physiological range, and increasing the dosage when physical stressors are present. |
| Databáze: | OpenAIRE |
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