Synergistic activities of type I (α, β) and type II (γ) murine interferons

Autor:	G. H. Werner, Aurelio Zerial, Kris Huygen, Ara G. Hovanessian, Ernesto Falcoff, Simon Stefanos
Rok vydání:	1982
Předmět:	Pharmacology Lymphokine Biology medicine.disease_cause Herpes simplex virus Biochemistry Cell culture Interferon Virology biology.protein medicine Interferon gamma Enzyme inducer Protein kinase A Interferon type I medicine.drug
Zdroj:	Antiviral Research. 2:227-239
ISSN:	0166-3542
DOI:	10.1016/0166-3542(82)90045-6
Popis:	Type I (alpha, beta) and type II (gamma) murine interferons are able to potentiate each other with respect to the inhibition of encephalomyocarditis (EMC) virus and of herpes simplex virus type 1 (HSV-1) multiplication in a murine cell line (DBT). Examination of two double-stranded RNA-dependent enzymes in DBT cells, the 2-5A synthetase and the 67,000 MW protein phosphokinase indicates that mixed interferon preparations act synergistically at least with respect to an increase in the activity of the former enzyme. The results obtained with gamma interferons of different origin and of different specific activity suggest that interferon itself, rather than the lymphokines present in the interferon preparations, is responsible for the synergistic effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8bfd631bcfe097b37b731642db138607 https://doi.org/10.1016/0166-3542(82)90045-6 Zobrazit plný text záznamu