Sleep spindles in rats with absence epilepsy
| Autor: | Evgenia Sitnikova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Spike-wave discharges medicine.diagnostic_test business.industry Rat model Sleep spindle Electroencephalography medicine.disease 03 medical and health sciences Epileptic discharge Epilepsy 030104 developmental biology 0302 clinical medicine Animal model Close relationship Medicine business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Sleep Spindles & Cortical Up States. 2:18-27 |
| ISSN: | 2559-9070 |
| DOI: | 10.1556/2053.01.2017.004 |
| Popis: | Absence epilepsy is an idiopathic generalized non-convulsive type of epilepsy associated with aberrant activity in the thalamocortical network. The common neuronal network mechanism of spike–wave discharges (a manifestation of absence epilepsy) and sleep spindles suggests a close relationship between them. This paper overviews electroencephalographic (EEG) properties of anterior sleep spindles in a genetic Wistar Albino Glaxo from Rijswijk (WAG/Rij) rat model of absence epilepsy. Epileptic discharges in WAG/Rij rats appear spontaneously, and their incidence increases with age. In epileptic rats, time–frequency profile of sleep spindles distinguished from that in non-epileptic subjects by shorter duration, lower intraspindle frequency, and contained less slow-wave components, etc. Some pro-epileptic modifications of spindle activity can also be observed in EEG in epileptic WAG/Rij rats. |
| Databáze: | OpenAIRE |
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