DI-017 Usage profile, effectiveness and safety of coformulated Rilpivirine/Emtricitabine/Tenofovir
| Autor: | JM Fernández Martín, D Gonzalez Vaquero, A Martos Rosa, M Gimeno Jordá, JA Morales Molina, J Urda Romacho, A Fayet Pérez |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Tenofovir business.industry Medication adherence Emtricitabine Emtricitabine/Tenofovir chemistry.chemical_compound chemistry Internal medicine Rilpivirine medicine General Pharmacology Toxicology and Pharmaceutics Adverse effect business Viral load medicine.drug Pantoprazole |
| Zdroj: | European Journal of Hospital Pharmacy. 22:A81.3-A82 |
| ISSN: | 2047-9964 2047-9956 |
| DOI: | 10.1136/ejhpharm-2015-000639.195 |
| Popis: | Background Rilpivirine/Emtricitabine/Tenofovir (RPV/FTC/TDF) is a single tablet regimen recommended for treatment-naive HIV patients with baseline viral load (VL) 1 Purpose To analyse the usage profile, effectiveness and safety of RPV/FTC/TDF. Material and methods Retrospective study conducted in a Primary Hospital between May 2013–Sept 2014. Patients included were those with HIV infection who started RPV/FTC/TDF treatment. Data were collected from electronic medical records: Demographics, previous antiretroviral therapy (ART), reason for treatment, immunovirological status, laboratory data (VL, CD4, c-LDL, Total Cholesterol) and adverse effects before/after start of RPV/FTC/TDF. Adherence was assessed by the dispensing records and the Simplified Medication Adherence Questionnaire (SMAQ) (patients were considered adherent with scores over 95%). Results RPV/FTC/TDF was initiated in 21/390 (5%) patients with ART. Age (years): 45 (range: 31–70); Male: 14/21 (68%). Patients with previous ART: EFV/FTC/TDF: 7; FTC/TDF/ATV/r: 2; 3TC/AZT/NVP: 1; 3TC/AZT/LPV/r: 1; ABC/AZT/LPV/r: 1; TDF/FTC/NVP: 1; FTC/TDF/ETV: 1; FTC/TDF/DRV/r: 1; DRV/r: 1; FTC/TDF: 1. Reasons for prescription: 17 ART-experienced (81%) and 4 ART-naive (19%). Pretreated reasons: 9 (53%) simplifications, 6 (36%) to avoid previous ART toxicity (EFV: 4, Protease Inhibitors: 2) and 2 (11%) others. Three patients were withdrawn (low adherence: 2, pantoprazole interaction: 1). Pre-treatment data: Adherence > 95% 7/17 (41%), VL 95%: 17/21 (80%), patients simplified to RPV/FTC/TDF who achieved >95% adherence: 6/9 (66%), VL 2 Only one patient experienced headaches during the first week with RPV/FTC/TDF. Conclusion RPV/FTC/TDF was used primarily as a strategy for simplification and to avoid ART toxicity, mainly due to EFV. All patients had undetectable VL, improved adherence (+39%), effectiveness (11% increase in CD4) and treatment was well tolerated. Lipid profile was improved too. References EACS Guidelines Version 7.02. June 2014 Sharma M, Saravolatz LD . J Antimicrob Chemothe 2013;(68):250–6 No conflict of interest. |
| Databáze: | OpenAIRE |
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