PHOTODYNAMIC THERAPY FOR LIVER CIRRHOSIS (EXPERIMENTAL STUDY)
| Autor: | P. V. Garelik, E. V. Mahiliavets |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Cirrhosis Hepatology Bilirubin Gastroenterology Connective tissue medicine.disease Amino acid Hydroxyproline chemistry.chemical_compound medicine.anatomical_structure Endocrinology chemistry Internal medicine Blood plasma medicine Hepatic stellate cell Alkaline phosphatase Surgery |
| Zdroj: | Annaly khirurgicheskoy gepatologii = Annals of HPB surgery. 20:17-26 |
| ISSN: | 2408-9524 1995-5464 |
| DOI: | 10.16931/1995-5464.2015417-26 |
| Popis: | Aim. To study the effects of photodynamic therapy for liver cirrhosis in experiment. Material and Methods. Liver cirrhosis was induced in 44 white rats-males Wistar rats using CCl4 in the experiment. Photolon at a dose of 3.0 mg/kg was intravenously introduced (tail vein) in experimental groups of animals in 1 day after the last injection of CCl4. In 3 hours laser irradiation of liver was performed at a dose of 10 j/cm2 with a wavelength of 670 nm. Morphological examination of liver tissue, electron microscopy, biochemical analysis of blood, determination of free amino acids in blood plasma were carried out. Results. There was reduction of connective tissue in liver parenchyma after photodynamic therapy. Hepatocytes' alternative changes and their lipid infiltration were drastically reduced. Infiltration corresponded to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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