Cotton gauze-hydrogel composites: Valuable tools for electrically modulated drug delivery

Autor:	Tania Spataro, Manuela Curcio, Umile Gianfranco Spizzirri, Fiore Pasquale Nicoletta, Nevio Picci, Francesca Iemma, Giuseppe Cirillo
Rok vydání:	2016
Předmět:	Materials science Polymers and Plastics General Chemical Engineering Composite number Kinetics 02 engineering and technology Polyethylene glycol Diclofenac Sodium 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound chemistry Acrylamide Drug delivery Self-healing hydrogels medicine Swelling medicine.symptom Composite material 0210 nano-technology
Zdroj:	International Journal of Polymeric Materials and Polymeric Biomaterials. 65:442-450
ISSN:	1563-535X 0091-4037
Popis:	Cotton gauze was inserted into a hydrogel network composed of acrylamide, sodium methacrylate, and polyethylene glycol dimethacrylate to fabricate an electroresponsive delivery system for wound dressing. The composite was characterized by swelling measurements, showing that shrinking or swelling depend on the applied voltage. The release profile of incorporated diclofenac sodium salt shows the possibility to modulate the kinetics by changes in the amplitude and duration of applied electric pulses. Mathematical models allow a characterization of release profiles, which are slower when an external voltage of 6, 12, and 18 V is applied, and faster at 24 V.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8be647295c1a03bc092ec29f4ecbeae8 https://doi.org/10.1080/00914037.2015.1129956 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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