| Autor: |
Daniel Matúš, Victoria Elisabeth Groß, Franziska Fiedler, Wilbert Berend Post, Alexander Bernd Knierim, Johanna Lena Schön, Torsten Schöneberg, Simone Prömel |
| Rok vydání: |
2023 |
| DOI: |
10.1101/2023.02.18.529090 |
| Popis: |
Adhesion G protein-coupled receptors (aGPCR) are unique molecules. They are able to transmit classical signals via G-protein activation (7TM-dependent/cissignaling) as well as to mediate functions solely through their extracellular N termini, completely independent of the seven transmembrane helices domain (7TM) and the C terminus (7TM-independent/N terminus-only/transfunction). This dual mode of action is highly unusual for GPCRs and allows for a plethora of possible cellular consequences. However, the physiological implications and molecular details of this N terminus-mediated signaling are not well understood. Here, we identify three distinct 7TM-independent/transfunctions of the aGPCR Latrophilin homolog LAT-1 in the nematodeCaenorhabditis eleganstogether regulating reproduction: sperm guidance, germline apoptosis and proliferative activity of germ cells in the gonadal stem cell niche. In these contexts, the receptor elicits its functions in a non-cell autonomous manner from adjacent somatic cells. These functions might be realized through alternative splicing of the receptor specifically generating N terminus-only variants. Thus, our findings shed light on the versatility of 7TM-independent/N terminus-only/transfunctions of aGPCR and discusses possible molecular details. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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