III. Mitt.: Induktion qualitativer Veränderungen der Ferritinfraktion durch hepatotrope Carcinogene / III: Alterations of the Ribosomal Ferritin-Fraction Induced by Hepatotropic Carcinogens

Autor:	Jürgen G. Meyer-Bertenrath, Wolfram Domschke
Rok vydání:	1970
Předmět:	Ferritin Nitroso Compounds biology Biochemistry Ribosomal protein Chemistry biology.protein RNA General Chemistry Ribosomal RNA Nucleotidyltransferase Ribosome Carcinogen
Zdroj:	Zeitschrift für Naturforschung B. 25:744-748
ISSN:	1865-7117 0932-0776
DOI:	10.1515/znb-1970-0718
Popis:	Liver ribosomes from rats pretreated with carcinogenic agents release a ferritin fraction which differs from that of normal ribosomes. This was demonstrated by disc-electrophoresis of the native protein and of the subunits produced by LiCl-urea-treatment. Moreover, the nucleoproteids into which those ribosomes dissociate during incubation with protease-free ribonuclease show a significant alteration in their electrophoretic pattern. - The Michaelis - constant of ribonuclease was found about hundredfold higher, which indicates that the superficial RNA structures are masked by the pathological ferritin to a greater extent than the RNA of normal ribosomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8bc7b1b5430ce64ffa8f0cc7234226cd https://doi.org/10.1515/znb-1970-0718 Zobrazit plný text záznamu