Descriptors of Malignant Non-mass Enhancement of Breast MRI
| Autor: | Mitsuhiro Tozaki, Tamiko Yoshida, Eisuke Fukuma, Yoshifumi Kuroki, Akiko Shimauchi, Youichi Machida |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease 030218 nuclear medicine & medical imaging Mass enhancement Correlation 03 medical and health sciences symbols.namesake 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis medicine symbols Breast MRI Radiology Nuclear Medicine and imaging Clinical significance Radiology business Student's t-test Fisher's exact test |
| Zdroj: | Academic Radiology. 23:687-695 |
| ISSN: | 1076-6332 |
| DOI: | 10.1016/j.acra.2016.01.014 |
| Popis: | Rationale and Objectives This study aims to investigate the clinical significance of malignant non-mass enhancement (NME) descriptors in breast magnetic resonance images by assessing their correlation to the presence of invasion or lymph node metastasis. Materials and Methods Three radiologists independently reviewed magnetic resonance images with malignant NMEs between January 2008 and December 2009. Distribution was assessed first, and then each of four internal enhancement patterns—clumped, clustered ring, branching, and hypointense area—was evaluated dichotomously (yes or no). Because clustered rings and hypointense areas were thought to be major structural elements of heterogeneous NMEs, they were also evaluated by integrating them into one collective descriptor we called the “heterogeneous structures.” Chi-square test, Fisher exact test, or Student t test was used to analyze differences of variables by each reviewer. Positive predictive values (PPVs) of descriptors in predicting presence of invasion or lymph node metastasis were calculated. P Results We included 131 malignant NMEs (76 in situ and 55 invasive) in 129 patients (two bilateral). All three observers' results showed clustered rings (PPVs 54.5%, 54.5%, 50.0%) ( P = 0.0005, 0.038, 0.029) and hypointense areas (PPVs 63.6%, 61.5%, 73.9%) ( P = 0.004, 0.024, 0.0006) to be significantly associated with invasion. When clustered rings and hypointense areas were integrated into heterogeneous structures, they were significantly associated with invasion (PPVs 54.3%, 53.3%, 51.8%) ( P = 0.0003, 0.016, 0.003). Conclusions The NME descriptors clustered rings, hypoechoic areas, and heterogeneous structures, assessed collectively, were associated with invasive breast cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|