Imaging of activated microglia with PET and [11 C]PK 11195 in corticobasal degeneration
| Autor: | Irina Mader, Jochen Karitzky, Albert C. Ludolph, Karsten Henkel, Jürgen W. Unger, Bernd Neumaier, Michaela Schmid, Gerhard Glatting, G. Bernhard Landwehrmeyer, Sven N. Reske |
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| Rok vydání: | 2004 |
| Předmět: |
Fluorodeoxyglucose
PK-11195 Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Neurodegeneration medicine.disease chemistry.chemical_compound medicine.anatomical_structure Neurology chemistry Positron emission tomography Basal ganglia Medicine Corticobasal degeneration Neuroglia Neurology (clinical) business Neuroscience medicine.drug Benzodiazepine receptor binding |
| Zdroj: | Movement Disorders. 19:817-821 |
| ISSN: | 0885-3185 |
| Popis: | Positron emission tomography (PET) using [11C]PK 11195, a ligand for peripheral benzodiazepine receptor binding sites, offers the opportunity to image activated microglia in vivo. This tool may therefore be used to display the occurrence of microglial activation in the course of neurodegeneration. A patient with the clinical diagnosis of corticobasal degeneration (CBD) and left-sided symptoms was studied using fluorodeoxyglucose (FDG) and [11C]PK 11195 PET. We found a marked right hemispheric hypometabolism and asymmetric microglial activation in corresponding areas of the basal ganglia and right temporal and parietal cortex. [11C]PK 11195 PET suggests involvement of microglial activation in the pathogenesis of CBD. © 2004 Movement Disorder Society |
| Databáze: | OpenAIRE |
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