Carotid intima-media thickness as a screening tool in cardiovascular primary prevention

Autor: Elpidio Calvo-Manuel, Jose L. Zamorano-Gómez, Sofía Garrido-Elustondo, Cristina Gallardo-Mayo, Antonio L. Aguilar-Shea
Rok vydání: 2010
Předmět:
Zdroj: European Journal of Clinical Investigation. 41:521-526
ISSN: 0014-2972
DOI: 10.1111/j.1365-2362.2010.02440.x
Popis: Eur J Clin Invest 2011; 41 (5): 521–526 Abstract Background and Objective Increased carotid intima-media thickness (CIMT) is associated with cardiovascular events. The purpose of this study was to identify advanced subclinical atherosclerosis in patients who are at low or intermediate risk. Methods Thousand hundred and eighteen Spanish subjects were prospectively enrolled in an ambulatory screening of cardiovascular risk (CVR). Three hundred and twenty patients aged over 30 years with low-intermediate CVR according to European SCORE function underwent carotid ultrasonography. Carotid IMT and plaque assessment were performed using high-resolution B-mode ultrasonography. Participants with abnormal CIMT were reclassified to high CVR. Results According to SCORE function, 104 patients (32·5%) were of low CVR and 216 (67·5%) of intermediate CVR. Mean carotid IMT was 0·62 ± 0·13 mm, and carotid plaque was found in 35 (10·9%) patients. Carotid ultrasonography changed the risk stratum in 59 (18·4%) patients, who were reclassified to high CVR. Reclassification was more frequent in the intermediate CVR group than in the low CVR group (22·7% vs. 9·6%, P = 0·005) and was associated to age (P = 0·002), history of arterial hypertension (P
Databáze: OpenAIRE
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