Effect oF β-Alanine on The Preparation of 4-Ethoxy-Cinnamic Acid
| Autor: | Nguyen To Hoai, Tran Thu Thuy, Tran Thi Yen Ngoc, Truong Khoi Nguyen, Nguyen Dang Nam, Nguyen Duy Hai, Cao Thi Thu Trang |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Alanine
Materials science 020209 energy 02 engineering and technology 010402 general chemistry 01 natural sciences Medicinal chemistry Cinnamic acid 0104 chemical sciences Corrosion inhibitor chemistry.chemical_compound symbols.namesake chemistry 0202 electrical engineering electronic engineering information engineering symbols Alkoxy group General Materials Science Raman spectroscopy |
| Zdroj: | The Open Materials Science Journal. 12:58-67 |
| ISSN: | 1874-088X |
| DOI: | 10.2174/1874088x01812010058 |
| Popis: | Objective:Cinnamic acid and its derivatives have a numerous potential applications in many different fields such as pharmacy, organic “building blocks”, and corrosion inhibitors.Method:It is well-known that Verley-Doebner modification is a high efficient method for the preparation of cinnamic acid derivaties, especially with the compounds containing electron-donating subtituents at para position in aromatic ring. In this paper, 4-ethoxy-cinnamic acid was synthesized according to Verley-Doebner reaction with the use of pyrine acting as catalyst and solvent. The effect of the β-alanine concentration on the conversion of the starting material of 4-ethoxy-benzaldehyde was thoroughly investigated using high performance liquid chromatography. The results showed that consuming of 8% of β-alanine would convert 100% of 4-ethoxy-benzaldehyde to 4-ethoxy-cinnamic acid.Result:The structure of the obtained 4-ethoxy-cinnamic acid was also confirmed using Fourier transform infrared spectroscopy, Raman spectroscopy, and Gas chromatography-Mass spectroscopy.Cinnamic acid and its derivatives have numerous potential applications in many different fields such as pharmacy, organic “building blocks”, and corrosion inhibitors. It is well-known that Verley-Doebner modification is a high efficient method for the preparation of cinnamic acid derivaties, especially with the compounds containing electron-donating subtituents at para position in aromatic ring. In this paper, 4-ethoxy-cinnamic acid was synthesized according to Verley-Doebner reaction with the use of pyrine acting as catalyst and solvent. The effect of the β-alanine concentration on the conversion of the starting material of 4-ethoxy-benzaldehyde was thoroughly investigated using high performance liquid chromatography. The results showed that consuming 8% of β-alanine would convert 100% of 4-ethoxy-benzaldehyde to 4-ethoxy-cinnamic acid. The structure of the obtained 4-ethoxy-cinnamic acid was also confirmed using Fourier transform infrared spectroscopy, Raman spectroscopy, and Gas chromatography-Mass spectroscopy. |
| Databáze: | OpenAIRE |
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