Solid phase synthesis of peptides containing a phosphoserine - sulfur mustard adduct

Autor:	Daan Noort, D.H.J.M. Platenburg, H.P. Benschop
Rok vydání:	1996
Předmět:	Phosphoramidite Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Sulfoxide Thiodiglycol Biochemistry Adduct Serine chemistry.chemical_compound Solid-phase synthesis Thioether Phosphoserine Drug Discovery Molecular Medicine Organic chemistry Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2007-2012
ISSN:	0960-894X
Popis:	Solid phase synthesis of peptides containing a serine thiodiglycol phosphate residue has been achieved by following a global on-resin phosphorylation strategy with a functionalized benzyl phosphoramidite. To preclude cleavage of the acid labile thiodiglycol phosphate ester during deprotection, the thioether functionality was temporarily protected as a sulfoxide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8bb4c67a0a9359ead651d5cc94f40fe2 https://doi.org/10.1016/0960-894x(96)00357-5 Zobrazit plný text záznamu Full Text from ScienceDirect