Novel thin-film nanofibrous composite membranes containing directional toxin transport nanochannels for efficient and safe hemodialysis application
| Autor: | Benjamin S. Hsiao, Yadong Zhu, Xufeng Yu, Xuefen Wang, Tonghui Zhang, Cheng Cheng |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Toxin transport Polyacrylonitrile Filtration and Separation 02 engineering and technology Carbon nanotube 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Polyvinyl alcohol 0104 chemical sciences law.invention chemistry.chemical_compound Membrane chemistry Chemical engineering law biology.protein General Materials Science Physical and Theoretical Chemistry Bovine serum albumin 0210 nano-technology Dialysis (biochemistry) Protein adsorption |
| Zdroj: | Journal of Membrane Science. 582:151-163 |
| ISSN: | 0376-7388 |
| DOI: | 10.1016/j.memsci.2019.04.006 |
| Popis: | Polymeric hemodialysis (HD) membranes with limited porosities, tortuous pores, and broad pore size distributions suffer from a trade-off between permeability-i.e., how fast toxins pass through the membranes-and selectivity-i.e., to what extent necessary proteins are retained. Here, a novel thin-film nanofibrous composite (TFNC) membrane, composed of an electrospun polyacrylonitrile (PAN) nanofibrous support layer and a chemically cross-linked polyvinyl alcohol (PVA) separation layer filled with heparin functionalized multi-walled carbon nanotubes (Hep-g-pMWCNTs), was demonstrated for efficient and safe HD application. Combining dialysis simulation experiments and pore-flow model, we demonstrated that the formation of free nanogaps at the interface between Hep-g-pMWCNTs and PVA matrix provided additional directional nanochannels for toxins to transport. The membranes showed efficient toxins removal without sacrificing selectivity (with the urea clearance of 88.2%, lysozyme clearance of 58.6%, and bovine serum albumin retention of 98.4% in a 4 h simulating dialysis). Especially, the efficiency in removing middle molecule toxins increased obviously compared with the values reported to date. Besides, the membranes exhibited excellent hemocompatibility: high resistance to protein adsorption, suppressed platelet adhesion, favorable anticoagulant activity, limited hemolysis ratio, and low complement activation. These facts suggested that the Hep-g-pMWCNTs/PVA/PAN TFNC membranes with superior comprehensive performances presented great potential for HD application. |
| Databáze: | OpenAIRE |
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