Sarcopenia of Respiratory Muscle in Lung Transplantation Patients Is Not a Poor Predictor of Early Survival
| Autor: | Seokkee Lee, J. Hur, Hyo Chae Paik, Seok Jin Haam, Kyung Sik Nam, H. Jung, Jin Gu Lee, Jee Won Suh, C. Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Transplantation medicine.medical_specialty business.industry medicine.medical_treatment medicine.disease 03 medical and health sciences 0302 clinical medicine Quartile Sarcopenia Internal medicine Pulmonary fibrosis medicine Cardiology Respiratory muscle Physical therapy Lung transplantation Surgery 030212 general & internal medicine Stage (cooking) Respiratory system Cardiology and Cardiovascular Medicine business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Heart and Lung Transplantation. 35:S136 |
| ISSN: | 1053-2498 |
| DOI: | 10.1016/j.healun.2016.01.373 |
| Popis: | Purpose: Candidates for lung transplantation (LTx) have been suffering from end stage lung disease for a long time and two third of them have reduced muscle mass. Sarcopenia has been considered as a poor prognostic factor from other solid organ transplantation. Respiratory muscle mass seems to be important for patients following Ltx to recover and patients with respiratory sarcopenia looks need longer recovery time. We measured respiratory muscle cross sectional area (CSA) and assessed the effect on early outcome after Ltx. Methods: Respiratory muscle SCA (pectoralis, intercostal, and paraspinal muscle) were acquired by analyzing a single slice of chest computed tomography at the carina. The images from 109 patients who underwent Ltx between 2010 Jan and 2015 July were available and Aquarius iNtuition viewer 4.4.11 was used to analyze the images. Results: Mean CSA was 58.24±15.82cm2. Highest CSA quartile (Q4; CSA 79.7±6.7) were more likely to be male (92.6% vs. 17.9%, p< 0.001) and have pulmonary fibrosis (85.2% vs.35.7%, p= 0.003) compared with lowest CSA quartile (Q1; CSA 39.4±5.2). Body mass index is positively correlated with CSA(r= 0.266, p< 0.005). Early postoperative recovery times including ventilator support day (32.9 ± 49.2 vs. 24.5 ± 39.9, p= ns), ICU stay day (28.4 ± 43.7 vs. 24.4 ± 35.9, p= ns) and hospital stay day (61.4 ± 48.2 vs. 50.8 ± 37.2, p= ns) showed longer trend in Q1 compared with Q4, but it was not significant. Early (≤ 30 days) mortality (7.1% vs. 11.1%, p= ns) and 90 day mortality (28.6% vs. 29.6%, p= ns) were not different between Q1 and Q4. But, 1 year survivals was better in Q1 compared with Q4 (66.6% vs. 46.0%, p= 0.04). Conclusion: Patients with respiratory sarcopenia seem to need longer postoperative recovery time after Ltx but it did not compromise early outcome. Even patient with high respiratory muscle mass showed poor early survival. We need further study regarding their long-term outcome. |
| Databáze: | OpenAIRE |
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