Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization
| Autor: | Ya-nan Li, Yue-Qing Hu, Liwan Fu, Dongmei Luo, Shufang Deng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Homocysteine business.industry 030209 endocrinology & metabolism Mendelian Randomization Analysis 030204 cardiovascular system & hematology medicine.disease Obesity Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Polymorphism (computer science) Methylenetetrahydrofolate reductase Internal medicine Meta-analysis Genotype Mendelian randomization Internal Medicine medicine biology.protein business |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12:1201-1212 |
| ISSN: | 1178-7007 |
| DOI: | 10.2147/dmso.s205379 |
| Popis: | Objective Numerous studies have explored the role of methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism and homocysteine (Hcy) concentration in obesity, but the results are inconsistent. Hence, we performed a meta-analysis implementing Mendelian randomization approach to test the assumption that the increased Hcy concentration is plausibly related to the elevated risk of obesity. Methods Eligible studies were selected based on several inclusion and exclusion criteria. Correlations between MTHFR C677T and obesity risk, MTHFR C677T and Hcy concentration in obesity, Hcy concentration, and obesity were estimated by ORs, effect size and standard mean difference with their corresponding 95% CIs, respectively. Furthermore, Mendelian randomization analysis was performed to estimate the relationship between Hcy level and obesity. Results Consequently, this meta-analysis implemented with Mendelian randomization approach was conducted among 8,622 cases and 29,695 controls. The results indicated that MTHFR C677T is associated with an increased risk of obesity (for T vs C: OR=1.06, 95% CI=1.02-1.10; for TT vs CC: OR=1.13, 95% CI=1.03-1.24). Moreover, in obese subjects, the pooled Hcy concentration in individuals of TT genotype was 2.91 mmol/L (95% CI: 0.27-5.55) higher than that in individuals of CC genotype. Furthermore, the pooled Hcy concentration in subjects with obesity was 0.74 mmol/L (95% CI: 0.36-1.12) higher than that in controls. The evaluated plausible OR associated with obesity was 1.23 for 5 μmol/L Hcy level increase. Conclusions Through this meta-analysis, we emphasize a strong relationship between Hcy level and obesity by virtue of MTHFR C677T polymorphism. |
| Databáze: | OpenAIRE |
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