Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride

Autor:	Mukund Tawar, Gauri Rathod, Kalpak Gajbhiye, Nawaz Hakam
Rok vydání:	2021
Předmět:	Matrix (mathematics) Materials science Chromatography BENIDIPINE HYDROCHLORIDE Transdermal
Zdroj:	Asian Journal of Pharmacy and Technology. :207-212
ISSN:	2231-5713 2231-5705
DOI:	10.52711/2231-5713.2021.00034
Popis:	The present research was designed to evaluate matrix type Benidipine Hydrochloride transdermal patches. So, the present work is an attempt to study effect of variation in Methocel E15LV concentration and study effect of hydrophilic and hydrophobic Methocel E15LV and Eudragit RL100 combination on release profile of Benidipine Hydrochloride. All prepared formulations were evaluated for physical and mechanical properties like thickness, moisture uptake, percent flatness, tensile strength, and percent elongation. An attempt was made to get a patch with suitable drug release property as well as physical and mechanical properties. A formulation containing Methocel E15LV 2% has shown good physical, mechanical and in-vitro drug release properties. It also showed good diffusion of Benidipine Hydrochloride across goat skin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b9c4dc320815c95f73b3e16919765dd https://doi.org/10.52711/2231-5713.2021.00034 Zobrazit plný text záznamu