Carcinoid syndrome and its sequelae
| Autor: | Gowri M Ratnayake, Christos Toumpanakis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Gastrointestinal system medicine.disease Gastroenterology digestive system diseases Pathophysiology Neuroendocrine tumour 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Carcinoid crisis Internal medicine Medicine Flushing Serotonin medicine.symptom business Organ system Carcinoid syndrome |
| Zdroj: | Current Opinion in Endocrine and Metabolic Research. 18:111-117 |
| ISSN: | 2451-9650 |
| DOI: | 10.1016/j.coemr.2021.02.006 |
| Popis: | The carcinoid syndrome is a result of a combination of peptides and amines commonly secreted by advanced neuroendocrine tumours, usually of small bowel primary origin, with a large overall tumour burden. Characteristically, this syndrome is defined by the presence of flushing, diarrhoea and wheezing, and serotonin is considered as the principal causative molecule. Carcinoid crisis carries a high mortality, and is, therefore, considered a medical emergency. In addition, long-term sequelae of the carcinoid syndrome include multiple organ systems, including the heart, gastrointestinal system, skin and neurological system. Management of carcinoid syndrome and its complications often requires a multi-faceted approach and should be carried out with simultaneous management of the neuroendocrine tumour. This review describes the pathophysiology, symptomatology, acute and chronic complications and management of the carcinoid syndrome. |
| Databáze: | OpenAIRE |
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