| Autor: |
Barnaby Young, Siew-Wai Fong, Zi Wei Chang, Kai Sen Tan, Angeline Rouers, Yun Shan Goh, Douglas Jie Wen Tay, Sean W. X. Ong, Ying Hao, Siang Li Chua, Jean-Marc Chavatte, Lin Cui, Matthew Tay, Raymond Tzer Pin Lin, Laurent Renia, Yee-Sin Leo, Justin Jang Hann Chu, David Lye, Lisa Fong Poh Ng |
| Rok vydání: |
2022 |
| DOI: |
10.21203/rs.3.rs-1281925/v1 |
| Popis: |
BackgroundOn 26 November 2021, the World Health Organization designated the B.1.1.529 lineage of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the fifth variant of concern, Omicron. Infections have quickly spread worldwide, but understanding of the viral dynamics and the cytokine and cellular immunological response during infection remain limited.MethodsDetailed patient-level data from 174 age-matched patients with sequence confirmed Omicron or Delta infection admitted to the National Centre for Infectious Diseases, Singapore were analyzed in an observational cohort study. Peripheral blood samples for measurement of SARS-CoV-2 immunological parameters were obtained from a subset. Respiratory samples were collected for viral cultures and correlated to corresponding PCR cycle threshold (Ct) values. ResultsOmicron and Delta variant infections in this hospitalized cohort were mild with only 3 (3%) and 14 (16%) developing pneumonia respectively. Omicron infections were more likely to present with sore throat (46.0 vs x23.0%, p=0.005). Neutrophil counts and C-reactive protein (CRP) were significantly lower among the Omicron cohort (Median neutrophil 2.95 [IQR 2.16 – 3.96] vs 4.60 [IQR 3.76 – 6.10] x 109/L , pConclusionsOmicron infections resulted in mild vaccine breakthrough illness in the majority of patients. Compared with Delta, Omicron infections were more frequently associated with upper respiratory tract infections, had lower viral loads, lower levels of pro-inflammatory cytokines and less dysregulated immune cell profiles. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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