The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neuronsin vitro
| Autor: | Laure Fronzaroli-Molinieres, Andrzej Bialowas, Norbert Ankri, Célia Gasselin, Philippe Gastrein, Edmond Carlier, Robert H. Cudmore, Emilie Campanac, Dominique Debanne |
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| Rok vydání: | 2011 |
| Předmět: |
0303 health sciences
Physiology Chemistry Resonance Stimulation Hippocampal formation Hyperpolarization (biology) Inhibitory postsynaptic potential In vitro 03 medical and health sciences 0302 clinical medicine Postsynaptic potential Excitatory postsynaptic potential Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | The Journal of Physiology. 589:3753-3773 |
| ISSN: | 0022-3751 |
| Popis: | Non-technical summary We determined here the role of the hyperpolarization-activated cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 pyramidal neurons the h-current has three main actions. In addition to setting intrinsic resonance frequency at ∼4 Hz, the h-current determines, through two main mechanisms, the temporal precision of action potentials evoked by excitatory postsynaptic potentials or following stimulation of inhibitory postsynaptic potentials (rebound spiking). We propose that h-channels participate in the fine tuning of oscillatory activity in hippocampal and neocortical networks. |
| Databáze: | OpenAIRE |
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