Characterization of a cryptic PML-RARA fusion by mate-pair sequencing in a case of acute promyelocytic leukemia with a normal karyotype and negative RARA FISH studies

Autor:	Beth A. Pitel, Linda B. Baughn, William R. Sukov, Rhett P. Ketterling, Patrick R. Blackburn, Sarah H. Johnson, Nicole L. Hoppman, Patricia T. Greipp, Jess F. Peterson, George Vasmatzis, Matthew J. Schultz, James B. Smadbeck, Christopher H. Cogbill, Karen L. Rech
Rok vydání:	2019
Předmět:	Acute promyelocytic leukemia Cancer Research medicine.medical_treatment fungi food and beverages Karyotype Chromosomal translocation Hematology Biology Mate pair medicine.disease Targeted therapy 03 medical and health sciences Leukemia Promyelocytic leukemia protein 0302 clinical medicine Oncology immune system diseases 030220 oncology & carcinogenesis medicine biology.protein Cancer research Neoplasm neoplasms 030215 immunology
Zdroj:	Leukemia & Lymphoma. 61:975-978
ISSN:	1029-2403 1042-8194
DOI:	10.1080/10428194.2019.1699081
Popis:	Acute promyelocytic leukemia (APL) is a time-critical hematologic neoplasm that is amenable to targeted therapy [1]. While the diagnosis of APL can be suspected based on the clinical presentation, ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b7db71149518a8a30bd070a6fbfdc13 https://doi.org/10.1080/10428194.2019.1699081 Zobrazit plný text záznamu