Pulmonary Exacerbations in Adults With Cystic Fibrosis
| Autor: | Gemma Stanford, Nicholas J. Simmonds, Kavita Dave |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty education.field_of_study business.industry Population MEDLINE Disease Critical Care and Intensive Care Medicine medicine.disease Cystic fibrosis Unmet needs Hypertonic saline 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) 030228 respiratory system medicine 030212 general & internal medicine Airway clearance technique Cardiology and Cardiovascular Medicine Intensive care medicine business education |
| Zdroj: | Chest. 159:93-102 |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2020.09.084 |
| Popis: | Pulmonary exacerbations (PExs) are significant life events in people with cystic fibrosis (CF), associated with declining lung function, reduced quality of life, hospitalizations, and decreased survival. The adult CF population is increasing worldwide, with many patients surviving prolonged periods with severe multimorbid disease. In many countries, the number of adults with CF exceeds the number of children, and PExs are particularly burdensome for adults as they tend to require longer courses and more IV treatment than children. The approach to managing PExs is multifactorial and needs to evolve to reflect this changing adult population. This review discusses PEx definitions, precipitants, treatments, and the wider implications to health-care resources. It reviews current management strategies, their relevance in particular to adults with CF, and highlights some of the gaps in our knowledge. A number of studies are underway to try to answer some of the unmet needs, such as the optimal length of treatment and the use of nonantimicrobial agents alongside antibiotics. An overview of these issues is provided, concluding that with the changing landscape of adult CF care, the definitions and management of PExs may need to evolve to enable continued improvements in outcomes across the age spectrum of CF. |
| Databáze: | OpenAIRE |
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