| Autor: |
Jia Yo Wu, Malosi Poma, Sheng Yang Lee, Duen Cheng Wang, Jen Chang Yang, Hong Da Wu |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Materials Science and Engineering: C. 32:440-446 |
| ISSN: |
0928-4931 |
| DOI: |
10.1016/j.msec.2011.11.016 |
| Popis: |
The purpose of this study was to prepare resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP) bone substitute with a resorption period of 3–6 months specifically designed for dental implantation surgery. A one-pot process was used to manufacture α-CSH and ACP. Granular particles of α-CSH/ACP (60/40) with diameters of 420–840 μm were prepared. In dissolution test, both α-CSH/ACP (60/40) and CSD displayed rapid dissolution in the first 20 days, followed by a remarkably slow dissolution rate to reach weight retention plateaus of around 13.5% ± 0.7% and 40.5% ± 1.4% at 90 days, respectively. The in vivo study showed no adverse effects as a consequence of any of the implanted materials. After 3 weeks, the defects treated with α-CSH/ACP (60/40) showed more new bone formation (21.1%) than the empty control (13.6%) ( p p in vivo resorption time within 3–6 months for α-CSH/ACP (60/40) was mathematically estimated by an extrapolation method. This biocompatible α-CSH/ACP (60/40) composite with a 3–6-month resorption period may be suitable for dental implantation surgery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect