Observations on the Intranasal Route of Infection in Experimental Poliomyelitis
| Autor: | E. W. Schultz, L. P. Gebhardt |
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| Rok vydání: | 1933 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 30:1010-1012 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-30-6773 |
| Popis: | It is generally recognized that while experimental poliomyelitis may be induced with regularity in monkeys inoculated with a potent virus by the intracerebral route, infection results much less frequently when the virus is instilled into the nasal passages. Since the natural infection in man occurs chiefly, if not entirely, by the nasal route, it is sometimes desirable, especially in certain experimental studies, to imitate closely the natural mode of infection. To be really serviceable any method employed must produce infection with considerable regularity. While the results of different investigators with the intranasal route of inoculation have been but meagerly reported, the general experience seems to have been that while infection by the intranasal route is possible, it is seldom realized in more than one-half of the monkeys so inoculated. At times less than a third of the animals develop the disease. In exceptional instances only have somewhat better results been reported. Rhoads1 and Weyer, Park a... |
| Databáze: | OpenAIRE |
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