Replacement of the phosphodiester linkage in oligonucleotides by an amide: Effect of backbone length on duplex stability with RNA complement
| Autor: | Romain M. Wolf, Alain De Mesmaeker, Sebastian Wendeborn, Chantal Jouanno |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Phosphoramidite Stereochemistry Oligonucleotide Dimer Organic Chemistry Clinical Biochemistry Pharmaceutical Science RNA Biochemistry chemistry.chemical_compound Deoxyribonucleotide chemistry Amide Drug Discovery Phosphodiester bond Molecular Medicine Molecular Biology Thioamide |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:447-452 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(97)00037-1 |
| Popis: | Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides with RNA complements and their conformational analysis are described and compared to previously reported amide containing oligonucleotides. In addition, the synthesis of a thioamide phosphoramidite dimer is reported. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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