The activity of ceftazidime-avibactam against gram-negative bacteria – pathogens of wound burn infection
| Autor: | N V Abramova, N A Gordinskaya, E V Sabirova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Klebsiella biology Klebsiella pneumoniae Pseudomonas aeruginosa Avibactam 030106 microbiology Ceftazidime biology.organism_classification medicine.disease_cause Ceftazidime/avibactam Antimicrobial Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Antibiotic resistance chemistry medicine 030212 general & internal medicine medicine.drug |
| Zdroj: | MediAl. :70-73 |
| ISSN: | 2225-0026 |
| DOI: | 10.21145/2225-0026-2019-2-70-73 |
| Popis: | Introduction.The most common mechanism for the resistance of gram-negative bacteria to various classes of antimicrobial agents, including carbapenems, is the production of beta-lactamases, enzymes that destroy the beta-lactam ring.Purpose of the study.To analyze the activity of ceftazidime/avibactam against pseudomonads and Klebsiella isolated in patients with severe thermal injury.Materials and methods.We analyzed 2553 isolates – pathogens of wound burn infection in patients with thermal injury treated in 2018–2019. Results and discussion. Phenotypically, 72,8% of the analyzed P. aeruginosa were resistant to carbapenems, while 56,3% of carbapenemresistant strains produce group Vim metal-beta-lactamases. Analysis of the effectiveness of ceftazidime/avibactam against P. aeruginosa showed its high efficiency, more than half of the strains (55,3%) were sensitive to the drug. The studied K. pneumoniae phenotypically in 63,1% were carbapenem-resistant. Among K. pneumoniae resistant to carbapenems, 89,3% of the strains revealed genes of serine KPC or OXA-48 like carbapenemases. In vitro ceftazidime/avibactam was active against two-thirds (72,7%) of K. pneumoniae strains.Сonclusions.1. Gram-negative microorganisms occupy 30,2% of the etiological structure of a wound burn infection. 2. Phenotypically 72,8% of Pseudomonas aeruginosa are resistant to carbapenems, 56,3% of them produce metal beta-lactamases. 3. 63,1% of Klebsiella pneumoniae isolated in patients with thermal injury are resistant to carbapenems, 89,3% of them carry cattle or OXA-48 genes like carbapenemases. 4. Ceftazidime / avibactam in vitro showed activity against P. aeruginosa and K. pneumoniae, with 55,3% and 72,7% of the strains, respectively, being sensitive. |
| Databáze: | OpenAIRE |
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