Biopharmaceutical study of suppositories containing nonsteroidal anti-inflammatory drugs

Autor:	T. A. Pankrusheva, N. D. Ogneshchikova, A. V. Nesterova, T. V. Orlova
Rok vydání:	2010
Předmět:	Pharmacology Aspirin Naproxen Nonsteroidal Chemistry medicine.drug_class Suppository Anti-inflammatory Bioavailability chemistry.chemical_compound Biopharmaceutical Drug Discovery medicine Sodium salicylate medicine.drug
Zdroj:	Pharmaceutical Chemistry Journal. 44:265-267
ISSN:	1573-9031 0091-150X
Popis:	The release of several nonsteroidal anti-inflammatory drugs (NSAIDs) including analgin, paracetamol, orthofen, naproxen, aspirin, and sodium salicylate from various lipophilic suppository bases has been investigated in vitro. Individual release patterns of NSAIDs from suppositories and the significant dependence of this process on the chemical nature of the base and surfactant were shown. It was found that a determining factor in the selection of a rational suppository base is the completeness of drug release from the suppositories because the correspondence of most of the studied suppositories to pharmacopoeial requirements for melting point and total deformation time did not guarantee that the drugs had high bioavailability. The optimum bases from a biopharmaceutical viewpoint for production of suppositories of the aforementioned NSAIDs were found. The results can be used by scientific and commercial laboratories for the creation of the optimum base for production of suppositories and other NSAID medicinal forms and for the development of a common approach to evaluating the quality of suppositories.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b5e5fa8d7a82dad7c04664580955a72 https://doi.org/10.1007/s11094-010-0445-2 Zobrazit plný text záznamu Plný text ve formátu PDF