Induction of sTNF-R1 and sTNF-R2 by interferon beta-1b in correlation with clinical and MRI activity
| Autor: | T. Bregenzer, Manfred Kaps, Patrick Oschmann, Horst Traupe, H. Diehl, A. Kern, S. B. Kuehne, C. Laske, N. Chatzimanolis, J. Kraus, R. Bauer, J. Tofighi |
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| Rok vydání: | 2001 |
| Předmět: |
Chemotherapy
medicine.medical_specialty business.industry medicine.medical_treatment Multiple sclerosis Interferon beta-1b General Medicine medicine.disease Gastroenterology Central nervous system disease Correlation Cytokine Neurology Interferon Internal medicine Statistical significance Immunology medicine Neurology (clinical) business medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 103:105-113 |
| ISSN: | 0001-6314 |
| DOI: | 10.1034/j.1600-0404.2001.103002105.x |
| Popis: | OBJECTIVES To investigate the influence of interferon (IFN) beta-1b on the serum levels of sTNF-R1, sTNF-R2 and TNF-beta in patients with multiple sclerosis (MS) in correlation with clinical and MRI activity. MATERIALS AND METHODS Serum samples were obtained every 3 months from 24 patients treated with 8 x 10(6) U of IFN beta-lb every other day (treatment group) and from 21 patients without any immunomodulatory therapy (control group) over a 15-month observation period. The cytokine levels were measured by ELISA. Cranial MRI was performed every 6 months to determine the burden of disease of every patient. RESULTS In the treatment group we found an obvious increase of sTNFR1 and sTNF-R2 (P < 0.001) and relatively stable serum levels of TNFbeta with no statistical significance (P = 0.56). In the control group, sTNF-R1 showed a significant decrease (P < 0.001) during the same observation period of 15 months. During the 15-month observation period, the MRI-responders group had significant larger mean AUC (area under the concentration-time curve) values of sTNF-R1 (P = 0.04) and sTNF-R2 (P = 0.01) when compared to the group of MRInonresponders. CONCLUSION The present data suggest that IFN beta-1b induces the expression and shedding of TNF-R1 and TNF-R2. The magnitude of an increase of sTNF-Rs may be a marker for the effectiveness of treatment with IFN beta-1b. |
| Databáze: | OpenAIRE |
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