Signaling Pathway in Early Brain Injury after Subarachnoid Hemorrhage: News Update
| Autor: | Chengyuan Ji, Gang Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Intracerebral hemorrhage medicine.medical_specialty Subarachnoid hemorrhage business.industry Mortality rate Inflammation Disease Brain damage medicine.disease nervous system diseases Brain ischemia 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Aneurysm Internal medicine Anesthesia medicine Cardiology cardiovascular diseases medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Acta Neurochirurgica Supplement ISBN: 9783319184968 |
| Popis: | The annual incidence of subarachnoid hemorrhage (SAH) caused by intracranial aneurysm rupture is approximately 10.5/10 million people in China, making SAH the third most frequently occurring hemorrhage of the intracranial type after cerebral embolism and hypertensive intracerebral hemorrhage. SAH caused by ruptured aneurysm leads to a mortality rate as high as 67 %, and, because of the sudden onset of this disease, approximately 12-15 % of patients die before they can receive effective treatment. Early brain injury (EBI) is the brain damage occurring within the first 72 h after SAH. Two-thirds of mortality caused by SAH occurs within 48 h, mainly as a result of EBI. With the development of molecular biology and medicine microscopy techniques, various signaling pathways involved in EBI after SAH have been revealed. Understanding these signaling pathways may help clinicians treat EBI after SAH and improve long-term prognosis of SAH patients. This chapter summarizes several important signaling pathways implicated in EBI caused by SAH. |
| Databáze: | OpenAIRE |
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