Peritoneal regression grading score (PRGS): first evidence for independent predictive and prognostic significance
| Autor: | Janina Baake, Giorgi Nadiradze, Rami Archid, Alfred Königsrainer, Hans Bösmüller, Marc Reymond, Wiebke Solass |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pleura and Peritoneum. |
| ISSN: | 2364-768X 2364-7671 |
| DOI: | 10.1515/pp-2023-0014 |
| Popis: | Objectives The peritoneal regression grading score (PRGS) is a four-tied pathologic score measuring tumor regression in biopsies from patients with peritoneal metastasis (PM) receiving chemotherapy. Methods This retrospective analysis of a prospective registry (NCT03210298) analyses 97 patients with isolated PM under palliative chemotherapy. We examined the predictive value of the initial PRGS for overall survival (OS) and the prognostic value of PRGS in repeated peritoneal biopsies. Results The 36 (37.1 %) patients with an initial mean PRGS≤2 had a longer median OS (12.1 months, CI 95 % 7.8–16.4) vs. 8.0 months (CI 95 % 5.1–10.8 months) in 61 (62.9 %) patients with PRGS≥3 (p=0.02) After stratification, the initial PRGS was an independent predictor of OS (Cox-regression, p Conclusions This is the first evidence for the independent predictive and prognostic significance of PRGS in PM. These encouraging results need validation in an adequately powered, prospective study. |
| Databáze: | OpenAIRE |
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