Translocation Associated Renal Cell Carcinoma in Pediatric Age Group: Review of Two Cases
| Autor: | Sandesh Parelkar |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry medicine.medical_treatment Urology TFE3 Chromosomal translocation Pediatric age urologic and male genital diseases medicine.disease eye diseases female genital diseases and pregnancy complications Nephrectomy Fusion gene Renal cell carcinoma Internal medicine medicine Adjuvant therapy Histopathology business neoplasms |
| Zdroj: | BAOJ Cancer Research & Therapy. 1:1-6 |
| Popis: | Renal Cell Carcinoma (RCC) is a rare pediatric renal neoplasm. Of these, Xp11.2 RCC is commonest, representing one-third of pediatric RCC. It is characterized by various translocations, all involving gene fusion with the transcription factor E3 (TFE3) gene at chromosome Xp11.2. It is usually diagnosed in an advanced stage and has poor prognosis. Surgical resection is the choice of treatment. Adjuvant therapy is not effective. We report 2 young children who presented with gross hematuria, and had RCC. Radical nephrectomy was done. Histopathology revealed Xp11.2 variant of RCC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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