Histological characteristics of knee menisci in patients with osteoarthritis
| Autor: | Jane C. Johnson, Kathryn Dominick, Kale Flory, Emily Tilton, Donet C. Main, Taylor L. Ernest, Dalton McDaniel, Peter Kondrashov |
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| Rok vydání: | 2017 |
| Předmět: |
030203 arthritis & rheumatology
Lateral meniscus 030222 orthopedics Pathology medicine.medical_specialty Histology business.industry General Medicine Osteoarthritis Knee Joint musculoskeletal system medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Calcinosis medicine Synovial fluid Fibrocartilage Anatomy business Nuclear medicine Medial meniscus Calcification |
| Zdroj: | Clinical Anatomy. 30:805-810 |
| ISSN: | 0897-3806 |
| DOI: | 10.1002/ca.22920 |
| Popis: | Existing data indicate knee menisci in patients with osteoarthritis (OA) show tearing, maceration, and fragmentation, but little is known about the change in histological structure. The aim of this study was to evaluate the change in the menisci histological structure in patients with clinically diagnosed knee OA. Fourteen patients undergoing surgical treatment of knee OA (OA group) and 14 cadaveric knees (control group) were assessed. Demographic data, medical history, synovial fluid, OA severity, medial meniscus (MM) tissue, and lateral meniscus (LM) tissue were collected from the OA group. Three nonconsecutive 10 μm cross-sectional tissue slices of menisci were analyzed for percentage of tissue calcification. Exact Mann-Whitney tests and Spearman correlation coefficients tested for relationships between variables. The major change in the histological structure of the menisci in patients with OA was calcification of the matrix, which was significantly greater in the OA group compared with the control group for MM (OA: 11.9%, cadaver: 5.17%; P |
| Databáze: | OpenAIRE |
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