| Autor: |
Atsushi Tsutsumi, Takahiro Nomi, Akihide Udagawa, Kiwamu Tanaka, Hironaka Kawasaki, Naoya Noguchi, Yutaka Horie, Takeaki Suou, Kenichi Harada, Goshi Shiota, Yosuke Kishimoto, Kenji Oyama |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Liver. 20:415-420 |
| ISSN: |
0106-9543 |
| Popis: |
We present a case of severe exacerbation of hepatitis after short-term corticosteroid therapy for chronic inflammatory demyelinating polyneuropathy (CIPD) with “latent” chronic hepatitis B showing no HBV-related antigens and antibodies. After corticosteroid pulse therapy for CIPD, the patient had severe exacerbation of hepatitis twice. Although she did not show any hepatitis B virus (HBV)-related antigens or antibodies, sequences of HBV were detected in serum and liver by a nested polymerase chain reaction. A sequence analysis of HBV at the second exacerbation showed that the G-to-A point mutation at nucleotide 1896 that converted codon 28 from tryptophan (TGG) to a stop codon (TAG) in the precore region resulted in amino acid change, which has been frequently observed in fulminant hepatitis and severe hepatitis in Japan. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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