Psychische Belastung, Immunfunktionen und Krankheitsentwicklungen Die psychoneuroimmunologische Perspektive
| Autor: | S. Gold, K.-H. Schulz |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Delayed wound healing
medicine.medical_specialty business.industry Multiple sclerosis Stressor Public Health Environmental and Occupational Health medicine.disease medicine.disease_cause Allostatic load Breast cancer Immune system Immunology Medicine Psychological stress business Intensive care medicine Psychoneuroimmunology |
| Zdroj: | Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 49:759-772 |
| ISSN: | 1437-1588 1436-9990 |
| DOI: | 10.1007/s00103-006-0006-8 |
| Popis: | Interdisciplinary psychoneuroimmunological (PNI) research increasingly demonstrates clinically relevant interrelations between psychological stressors and the onset or progression of chronic diseases. Disturbances of the bi-directional interaction between the nervous system, the immune system and the endocrine system have been hypothesized to be implicated in several diseases. Here, we review evidence from psychoneuroimmunology within the theoretical framework of allostatic load to conceptualize some of these associations. Interdisciplinary PNI research investigating the importance of psychological stress for the higher incidence of infections, decreased responses to vaccinations and delayed wound healing is reviewed. Furthermore, the literature supporting similar associations with regard to progression of oncological diseases and autoimmune disorders is reviewed with a focus on breast cancer and multiple sclerosis. The accumulating evidence regarding the importance of neuroendocrine-immune interaction in these diseases may thus lead to novel insights into pathogenetic mechanisms and could contribute to the development of novel preventive and therapeutic strategies. |
| Databáze: | OpenAIRE |
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