Calcium cross-linked zwitterionic hydrogels as antifouling materials
Autor: | Nandanan Erathodiyil, Jackie Y. Ying, Hong Wu, Hong Fang Lu, Hsi-Min Chan, Yiran Zheng |
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Rok vydání: | 2020 |
Předmět: |
chemistry.chemical_classification
Acrylate Materials science Lysine 02 engineering and technology Polymer 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Biofouling chemistry.chemical_compound Monomer chemistry Mechanics of Materials Self-healing hydrogels Materials Chemistry Biophysics General Materials Science Implant 0210 nano-technology Biosensor |
Zdroj: | Materials Today Communications. 23:100950 |
ISSN: | 2352-4928 |
Popis: | Current biomedical devices often suffer in lifetime due to proteins, cells and bacteria adherence to the implants, forming dense collagenous capsule around these implants. Bio-fouling and foreign body reactions would induce inflammatory responses, and may give rise to infection and/or implant rejection. Antifouling materials are widely used to combat this costly and complicated problem. However, existing materials do not completely prevent foreign body reactions, and hence, may not be suitable for long-term in vivo applications. Herein we show that cross-linking polymers with calcium and a zwitterionic amino acid monomer, methacryloyl- l -lysine (MLL), produces a novel antifouling, biocompatible hydrogel. We used 6 common acrylate monomers and different concentrations of MLL to create this material. Hydrogel with 30 mol% MLL was best at preventing the attachment of cells, proteins and bacteria. The ultralow-fouling hydrogel resisted the formation of capsule for at least 2 months when subcutaneously implanted in mice. The zwitterionic hydrogels are chemically defined, inexpensive to make, highly porous, and moldable. They are promising as antifouling biomaterials that may improve the performance of medical devices such as biosensors, drug-releasing devices, tissue scaffolds and artificial organs. |
Databáze: | OpenAIRE |
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