Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
| Autor: | Byung-Soo Koo, Dong-Il Kim, Sok Cheon Pak, Seongmi Lee, Boo Ahn Shin, Songhee Jeon, Cai Hua, Seung Tack Oh |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pharmacology Cell cycle checkpoint biology Physiology Chemistry Cell cycle medicine.disease biology.organism_classification nervous system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Angelica gigas Apoptosis Cell culture Glioma medicine Cancer research Neuroglia Cytotoxic T cell neoplasms 030217 neurology & neurosurgery |
| Zdroj: | The Korean Journal of Physiology & Pharmacology. 23:29 |
| ISSN: | 2093-3827 1226-4512 |
| DOI: | 10.4196/kjpp.2019.23.1.29 |
| Popis: | Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of this plant. In this study, we evaluated the inhibitory activity and related mechanism of action of decursin against glioblastoma cell line. Decursin demonstrated cytotoxic effects on U87 and C6 glioma cells in a dose-dependent manner but not in primary glial cells. Additionally, decursin increased apoptotic bodies and phosphorylated JNK and p38 in U87 cells. Decursin also down-regulated Bcl-2 as well as cell cycle dependent proteins, CDK-4 and cyclin D1. Furthermore, decursin-induced apoptosis was dependent on the caspase activation in U87 cells. Taken together, our data provide the evidence that decursin induces apoptosis in glioblastoma cells, making it a potential candidate as a chemotherapeutic drug against brain tumor. |
| Databáze: | OpenAIRE |
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