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Objective This paper aims to explore the influence of family function, work engagement, and sleep on the mental health of nurses in China's top three hospitals. Method The convenience sampling method was adopted to select 1147 clinical nurses from Taihe Hospital Affiliated to Hubei University of Medicine, during the period of August-September 2018 as the survey subjects. APGAR, UWES-9, PSQI,SCL-90 were employed to conduct a questionnaire survey on nurses’ family function, work engagement, sleep quality, and mental health status. Correlation analysis was performed to explore the relationship between clinical nurses’ mental health and family function, work engagement, and sleep quality. Multiple linear regression analysis and structural equation model were adopted to analyze the influencing factors of clinical nurses' mental health. Results Multiple linear regression analysis demonstrated that the main influencing factors of clinical nurses’ mental health include the length and emotional degree of family function, sleep quality, and the vitality dimension in work engagement (with t values of 1.996, -3.313, 17.524, and − 2.571, respectively, P |