New macromolecular carriers for drugs. I. Preparation and characterization of poly(oxyethylene-b-isoprene-b-oxyethylene) block copolymer aggregates

Autor:	Karel Petrak, A. Rolland, John Edward O'mullane, Peter Goddard, L. Brookman
Rok vydání:	1992
Předmět:	Materials science Aqueous solution Polymers and Plastics General Chemistry Micelle Controlled release Surfaces Coatings and Films Polymerization Drug delivery Polymer chemistry Materials Chemistry Copolymer Drug carrier Macromolecule
Zdroj:	Journal of Applied Polymer Science. 44:1195-1203
ISSN:	1097-4628 0021-8995
DOI:	10.1002/app.1992.070440709
Popis:	This work describes the formation of discrete micelles (⋍ 0.1 μm) from ABA poly(oxyethylene-b-isoprene-b-oxyethylene) block copolymers in water. An efficient labeling of the micelles by polymerization of [14C]-styrene within the hydrophobic core is also described. These micellar nanoparticles are being considered as promising materials for controlled release and/or site-specific drug delivery systems. In experimental animals the micelles remained in circulation with a half-life in excess of 50 h. Our results demonstrate the advantages of using block copolymers for the preparation of “perfect” biocompatible surfaces such as are required for well-tolerated, long-circulating particulate drug carriers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::8b2095d0328b2f4ca85e0d7351c60996 https://doi.org/10.1002/app.1992.070440709 Zobrazit plný text záznamu Plný text